2-Furoyltrifluoroacetone (4,4,4-Trifluoro-1-(2-furyl)-1,3-butanedione, CAS 326-90-9) is a fluorinated β-diketone carrying both a furan ring and a trifluoromethyl group. Supplied as a clear liquid with >98% purity, it serves as a versatile building block for ligand chemistry, heterocycle synthesis and materials research.
As a ligand, it is used directly to prepare luminescent terbium (Tb III) and lanthanide (Ln III) complexes for OLEDs and displays; such complexes have shown a quantum efficiency of 77% and a lifetime of 842 μs.
Its several functional groups give multiple synthetic handles. The furan ring can be modified through Diels-Alder reactions with electron-deficient dienophiles or by electrophilic substitution, while the 1,3-diketone unit condenses with hydrazine to give pyrazoles, with hydroxylamine to give isoxazoles and with urea to give pyrimidines. These heterocycles are studied as active pharmaceutical ingredients in anticancer and anti-inflammatory research.
- Ligand for synthesising luminescent Tb(III) and Ln(III) complexes for OLEDs and displays.
- Precursor for pyrazoles via reaction with hydrazine.
- Starting material for isoxazoles and pyrimidines using hydroxylamine or urea.
- Building block for API candidates in anticancer and anti-inflammatory drug discovery.
- Furan-based substrate for Diels-Alder and electrophilic substitution chemistry.
| Brand | Ossila |
|---|---|
| CAS number | 326-90-9 |
| Molecular formula | C8H5F3O3 |
| Purity | >98% |
| Category | — |
| Pack sizes | 25 g, 50 g |
| Physical form | Clear liquid |
| Storage | — |
- Product code: B1621
- Full Name: 4,4,4-Trifluoro-1-(2-furyl)-1,3-butanedione
- Synonyms: Perfluoroacetyl(2-furoyl)methane
- Molecular Weight: 206.12 g/mol
- Melting Point: 19 °C – 21 °C
- Boiling Point: 203 °C at 760 mmHg
- Relative Density: 1.391 g/mL at 25 °C
—
—