3,3-Difluoropiperidine hydrochloride (CAS 496807-97-7) is the hydrochloride salt of a piperidine ring carrying two fluorine atoms on the 3-position. Piperidine derivatives of this kind appear widely in active pharmaceutical ingredients (APIs), and this gem-fluorinated version is supplied as a cream/beige powder with a purity of >98%.
The compound is readily attached to molecular scaffolds by amination, making it a convenient fluorinated heterocyclic building block. In published work, introducing the 3,3-difluoropiperidine group raised the potency of an apelin receptor agonist, lowering its EC50 from 162 nM to 6.5 nM, and it has also been linked to 1600-fold selectivity in compounds targeting estrogen receptor positive breast cancer.
Beyond drug design, functionalizing molecules with this building block yields 19F NMR probes that can be used without deuterated solvents or internal standards. It suits research in medicinal chemistry, biochemistry and NMR methods.
- Building block for introducing a gem-difluorinated piperidine unit into pharmaceutical active ingredients.
- Attachment to molecular scaffolds through amination reactions.
- Medicinal chemistry work aimed at improving potency and selectivity of drug candidates, such as apelin receptor agonists.
- Preparation of 19F NMR probes usable without deuterated solvents or internal standards.
- Biochemistry research involving fluorinated piperidine derivatives.
| Brand | Ossila |
|---|---|
| CAS number | 496807-97-7 |
| Molecular formula | C5H10ClF2N |
| Purity | >98% |
| Category | — |
| Pack sizes | 1 g, 2 g, 5 g |
| Physical form | Cream/beige powder |
| Storage | — |
- Product code: B2571
- Molecular Weight: 157.59 g/mol
- Synonyms: 3 3-Difluoropiperidine HCl, 3,3-Difluoropiperidinium chloride
- Classification / Family: Fluorinated building block, Heterocyclic building blocks, Piperidine derivatives, APIs
- Melting Point: 243 °C – 247 °C
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