Ossila 3,3-Difluoropyrrolidine hydrochloride B2281

3,3-Difluoropyrrolidine hydrochloride (CAS 163457-23-6) is the hydrochloride salt of a fluorinated pyrrolidine, in which the ring nitrogen is protonated by hydrochloric acid. Supplied by Ossila as a white powder with >97% purity, it serves as a non-aromatic heterocyclic amino building block for drug discovery, organic synthesis and ferroelectric materials research.

In medicinal chemistry, the compound is used to attach a fluorinated pyrrolidine unit to target molecules through nucleophilic substitution. The two fluorine atoms can raise the potency of active pharmaceutical ingredients and help them pass through cell membranes.

Once deprotonated, the amine is able to bind to metal centres, opening a route to ferroelectric complexes. One example is the lead-free hybrid organic-inorganic ferroelectric (3,3-difluoropyrrolidinium)2ZnCl4·H2O, prepared from 3,3-difluoropyrrolidine, which exhibits a spontaneous polarization of 0.4 μC/cm2.

• Introducing fluorinated pyrrolidine groups into drug candidates via nucleophilic substitution.
• Building active pharmaceutical ingredients with improved potency and cell membrane permeability.
• Preparing hybrid organic-inorganic ferroelectrics such as (3,3-difluoropyrrolidinium)2ZnCl4·H2O.
• General organic synthesis as a fluorinated heterocyclic building block.

• Product code: B2281
• M​olecular Weight: 143.56 g/mol
• Melting Point: 134 °C
• Classification / Family: Fluorinated building block, Heterocyclic building block, APIs, Ferroelectrics

—

—