3,4,5-Trifluoroaniline (CAS 163733-96-8, C6H4F3N) is a fluorinated aniline building block carrying fluorine atoms at the 3-, 4- and 5-positions of the ring. Supplied at >98% purity as grey/purple crystals, it serves researchers working on active pharmaceutical ingredients, ligands and light-emitting materials.
Because the three fluorine substituents make the amine electron deficient, chemists frequently include it when exploring the substrate scope of new organic reactions. It has been used to build a capsid assembly modulator that blocks hepatitis B virus replication, and it can functionalize single wall carbon nanotubes (SWCNTs) in a one-pot reaction with sodium nitrite and chlorosulfonic acid, creating organic color centers that fluoresce at longer wavelengths than the native E11 nanotube emission.
In optoelectronics, a quasi-2D perovskite film made from lead bromide and 3,4,5-trifluoroaniline has reached a maximum luminance of 1.2 × 10 3 cd/m 2 with current efficiency up to 0.3 cd/A.
- Electron-deficient aniline substrate for substrate scope studies in organic synthesis.
- Building block for drug discovery, including synthesis of a hepatitis B capsid assembly modulator.
- Functionalization of single wall carbon nanotubes to generate organic color centers with red-shifted fluorescence.
- Organic cation for quasi-2D lead bromide perovskite films in light-emitting diode research.
- Fluorinated building block for ligand preparation.
| Brand | Ossila |
|---|---|
| CAS number | 163733-96-8 |
| Molecular formula | C6H4F3N |
| Purity | >98% |
| Category | — |
| Pack sizes | 5 g, 10 g, 25 g, 50 g |
| Physical form | Grey/purple crystals |
| Storage | — |
- Product code: B2481
- Molecular Weight: 147.10 g/mol
- Synonyms: 3,4,5-Trifluorobenzenamine
- Melting Point: 61 °C – 64 °C
- Classification / Family: Fluorinated building block, APIs, Ligands, OLEDs
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