Ossila 3-(4-Fluorophenyl)-1-isopropylindole B1691

3-(4-Fluorophenyl)-1-isopropylindole (CAS 93957-49-4) is a fluorinated heterocyclic building block based on indole, carrying an isopropyl group at the 1-position and a 4-fluorophenyl group at the 3-position. It serves as an intermediate in the synthesis of active pharmaceutical ingredients and dyes for drug discovery and photonics work.

This indole forms the core structure of Fluvastatin, a medicine prescribed for hypercholesterolemia to help prevent cardiovascular disease. Researchers have prepared derivatives of this scaffold that markedly lowered serum total cholesterol, triglycerides and low-density lipoprotein. A typical route first installs an aldehyde at the 2-position through a Vilsmeier-Haack reaction, then elaborates that aldehyde by Claisen-Schmidt condensation.

Beyond pharmaceutical chemistry, the compound displays non-linear optical behaviour: an electron-withdrawing substituent on the indole raises the hyperpolarizability coefficient and improves the non-linear optical response. It is supplied as an off-white to pale beige powder with a purity above 97%.

• Intermediate for synthesising Fluvastatin-type compounds and other APIs in drug discovery.
• Starting scaffold for anti-hyperlipidemic indole derivatives via Vilsmeier-Haack formylation and Claisen-Schmidt condensation.
• Building block for dyes and photonic materials.
• Research into non-linear optical properties of substituted indoles.
• Biochemistry studies of indole derivatives, such as their interaction with serum albumin.

• Product code: B1691
• Full Name: 3-(4-Fluorophenyl)-1-isopropyl-1H-indole
• Synonyms: 1-Isopropyl-3-(4-fluorophenyl)indole
• M​olecular Weight: 253.32 g/mol
• Melting Point: 95 °C – 98 °C
• Classification / Family: Fluorinated building block, heterocyclic building block, APIs, Photonics

Handle according to the MSDS provided by the manufacturer for this compound.

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