3′-Bromo-4′-fluoroacetophenone (CAS 1007-15-4), also known as 1-(3-bromo-4-fluorophenyl)ethanone, is a halogenated acetophenone building block from Ossila. The aromatic ring carries a bromide in the meta position and a fluoride in the para position relative to the acetyl group, giving chemists several reactive handles for straightforward synthesis.
The compound serves as a starting material for chalcones, α,β-unsaturated ketones studied in drug discovery, liquid crystals and optical materials. It can also be converted into an acetyl-functionalized carbazole using a tandem Suzuki-coupling/SNAr route. Acetophenones with para/meta substitution have been reported to show antimicrobial activity, with inhibitory concentrations reaching as low as 246 µM.
The material is supplied at >98% purity as a yellow to light brown powder or crystals, with a melting point of 52 °C – 57 °C.
- Precursor for the synthesis of chalcone derivatives used in drug discovery, liquid crystals and optical materials.
- Starting material for acetyl-functionalized carbazoles via a tandem Suzuki-coupling/SNAr approach.
- Synthesis intermediate for active pharmaceutical ingredients (APIs).
- Fluorinated and brominated building block for research into substituted acetophenones with antimicrobial activity.
| Brand | Ossila |
|---|---|
| CAS number | 1007-15-4 |
| Molecular formula | C8H6BrFO |
| Purity | >98% |
| Category | — |
| Pack sizes | 5 g, 10 g, 25 g, 50 g |
| Physical form | Yellow/light brown powder/crystals |
| Storage | — |
- Product code: B3361
- Full Name: 1-(3-Bromo-4-fluorophenyl)ethanone
- Molecular Weight: 217.04 g/mol
- Synonyms: 1-(3-Bromo-4-fluorophenyl)ethan-1-one, 1-Acetyl-3-bromo-4-fluorobenzene
- Melting Point: 52 °C – 57 °C
- Classification / Family: Fluorinated building blocks, Brominated building blocks, Acetophenone building blocks, APIs, Chalcone precursors, Carbazole precursors
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