3-Bromo-5-fluorophenol (CAS 433939-27-6) from Ossila is a halogenated phenol building block carrying hydroxy, bromo and fluoro groups on one aromatic ring. Supplied as a white powder with a purity above 98%, it serves as a versatile scaffold in drug discovery, medicinal chemistry and general organic synthesis.
Each of the three substituents offers its own route for modification. The hydroxy group takes part in nucleophilic substitution and Mitsunobu reactions, and the bromine atom is a convenient handle for metal-catalysed cross-coupling. The fluorine can either be displaced by nucleophiles through nucleophilic aromatic substitution or kept in the final structure, where it can improve the binding affinity of the resulting active pharmaceutical ingredient (API).
The compound has been used to prepare anticancer 3,4'-substituted diaryl guanidinium derivatives, which showed an inhibition of 4.07 ± 0.10 µM against the human promyelocytic leukaemia (HL-60) cell line. It is offered in 5 g, 10 g, 25 g and 50 g packs.
- Molecular scaffold for the synthesis of active pharmaceutical ingredients (APIs).
- Starting material for anticancer 3,4'-substituted diaryl guanidinium derivatives.
- Substrate for metal-catalysed cross-coupling via its bromo group.
- Building block for Mitsunobu and nucleophilic substitution reactions at the hydroxy group.
- Fluorinated building block for drug discovery and medicinal chemistry research.
| Brand | Ossila |
|---|---|
| CAS number | 433939-27-6 |
| Molecular formula | C6H4BrFO |
| Purity | >98% |
| Category | — |
| Pack sizes | 5 g, 10 g, 25 g, 50 g |
| Physical form | White Powder |
| Storage | — |
- Product code: B3231
- Molecular Weight: 191.00 g/mol
- Synonyms: 3-Fluoro-5-Bromophenol
- Classification / Family: Fluorinated building block, Halogenated building blocks, Phenol building blocks, APIs
- Melting Point: 36 °C – 40 °C
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