3-Chloro-5-fluoroaniline (CAS 4863-91-6) is a fluorinated aniline building block carrying a chlorine atom at the 3-position and a fluorine atom at the 5-position of the ring. Supplied as a clear liquid with a purity above 97%, it serves drug discovery, medicinal chemistry and biochemistry research.
Its main role is in the preparation of active pharmaceutical ingredients (APIs). It has been used to build antiviral compounds aimed at the influenza A H1N1 virus, and it is the starting material for a tetrahydroquinoline-based glucocorticoid receptor agonist for inflammation treatment, where it reacts with acetone and iodine in a Skraup reaction.
The amine group allows the molecule to be attached to scaffolds by reductive amination and nucleophilic substitution, while the halogen substituents open routes to further modification through palladium-catalyzed carbon-carbon coupling and nucleophilic aromatic substitution.
- Synthesis of antiviral API candidates targeting the influenza A H1N1 virus.
- Preparation of tetrahydroquinoline-based glucocorticoid receptor agonists for inflammation research via the Skraup reaction.
- Incorporation into molecular scaffolds through reductive amination and nucleophilic substitution.
- Further functionalization by palladium-catalyzed carbon-carbon coupling and nucleophilic aromatic substitution.
- Building block for drug discovery, medicinal chemistry and biochemistry research.
| Brand | Ossila |
|---|---|
| CAS number | 4863-91-6 |
| Molecular formula | C6H5ClFN |
| Purity | >97% |
| Category | — |
| Pack sizes | 2 g, 5 g, 10 g |
| Physical form | Clear liquid |
| Storage | — |
- Product code: B2911
- Molecular Weight: 145.56 g/mol
- Synonyms: 3-Chloro-5-fluorobenzenamine
- Classification / Family: Fluorinated building blocks, Aniline building blocks, APIs
- Boiling Point: 226 °C at 760 mmHg
- Relative Density: 1.45 g/mL
—
—