3-Fluoro-2-pyridinecarbonitrile (CAS 97509-75-6), also known as 3-fluoropicolinonitrile or 2-cyano-3-fluoropyridine, is a pyridine derivative carrying a nitrile group at the 2-position and a fluorine atom at the 3-position. Supplied as white crystals with a purity above 97%, it serves as a versatile intermediate for active pharmaceutical ingredients and phosphorescent dyes.
The fluorine-bearing carbon is open to nucleophilic aromatic substitution, which lets chemists couple the pyridine ring onto chromophores such as carbazoles to build aggregation-induced emission (AIE) molecules. The same approach is used in medicinal chemistry, where attaching this unit to negative allosteric modulator small molecules has improved binding affinity to glutamate receptors in research on central nervous system diseases.
The nitrile group also reacts with hydrazine in bioorthogonal chemistry to give tetrazines, which can then take part in tetrazine ligation and [4+1] cycloaddition reactions.
- Synthesis intermediate for active pharmaceutical ingredients.
- Building block for aggregation-induced emission materials via coupling to carbazole chromophores.
- Preparation of phosphorescent dyes.
- Medicinal chemistry work on negative allosteric modulators targeting glutamate receptors.
- Preparation of tetrazines with hydrazine for tetrazine ligation and [4+1] cycloaddition.
| Brand | Ossila |
|---|---|
| CAS number | 97509-75-6 |
| Molecular formula | C6H3FN2 |
| Purity | >97% |
| Category | — |
| Pack sizes | 5 g, 10 g, 25 g |
| Physical form | White crystals |
| Storage | — |
- Product code: B2611
- Molecular Weight: 122.10 g/mol
- Synonyms: 2-Cyano-3-fluoropyridine, 3-fluoropicolinonitrile, 3-Fluoro-pyridine-2-carbonitrile
- Melting Point: 27 °C – 32 °C
- Classification / Family: Fluorinated building blocks, Heterocyclic building blocks, APIs, Aggregation-induced emission materials, Phosphorescence
—
—