3-Fluoro-4-hydroxybenzaldehyde (CAS 405-05-0) from Ossila is a fluorinated benzaldehyde building block with a fluorine atom at the 3-position and a hydroxy group at the 4-position. Supplied as a beige powder with >97% purity, it serves as an intermediate in drug discovery, medicinal chemistry and biochemistry research, particularly for chalcones and curcumins.
Its several functional groups make it straightforward to work into synthetic routes. Aldol condensation with ketones gives curcuminoid analogues, and derivatives prepared this way have shown a half maximal inhibitory concentration of 0.75 μM against the human ovarian cancer cell line A2780. Condensation of the aldehyde with phenylhydrazine derivatives yields hydrazones that strongly inhibit macrophage migration, relevant to anti-inflammatory studies.
The compound can also be taken through a Wittig reaction to prepare caffeic acid phenylethyl amide derivatives, which have been studied for cytoprotective activity against peroxides. It is also known as 2-fluoro-4-formylphenol and is available in 5 g and 10 g packs.
- Synthesis of curcuminoid analogues with ketones by aldol condensation for anticancer research.
- Preparation of chalcone and curcumin intermediates for pharmaceutical active ingredients.
- Production of hydrazone derivatives via aldehyde-amine condensation for studies of macrophage migration inhibition.
- Synthesis of caffeic acid phenylethyl amide derivatives through Wittig reaction for cytoprotection research.
- General building block for medicinal chemistry and drug discovery work.
| Brand | Ossila |
|---|---|
| CAS number | 405-05-0 |
| Molecular formula | C7H5FO2 |
| Purity | >97% |
| Category | — |
| Pack sizes | 5 g, 10 g |
| Physical form | Beige powder |
| Storage | — |
- Product code: B2591
- Molecular Weight: 140.11 g/mol
- Synonyms: 2-Fluoro-4-formylphenol
- Classification / Family: Fluorinated building blocks, Benzaldehyde building blocks, APIs
- Melting Point: 121 °C – 124 °C
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