3-Fluoro-4-iodopyridine (CAS 22282-75-3) is a fluorinated pyridine building block carrying a fluorine atom at the 3-position and an iodine atom at the 4-position. Supplied by Ossila at >97% purity as an off-white powder or fibres, it serves as a synthesis intermediate for active pharmaceutical ingredients (APIs) and synthetic ligands.
Its two different halogen substituents make it a versatile heterocyclic scaffold for drug discovery, medicinal chemistry and general organic synthesis. One documented route to the antibiotic Eudistomin T starts with a Suzuki coupling between this compound and (2-pivaloylaminophenyl)boronic acid; lithiation then gives a trisubstituted pyridine, and a final cyclization completes the target molecule.
The compound is also a key starting material for β-carboline, a structure of interest in anti-cancer treatment, neuroenhancement and neuroprotection research.
- Building block and molecular scaffold for the synthesis of active pharmaceutical ingredients.
- Substrate for Suzuki coupling and lithiation steps, as in the synthesis of the antibiotic Eudistomin T.
- Key intermediate in the preparation of β-carboline compounds.
- Precursor for synthetic ligands in organic synthesis.
- Fluorinated heterocyclic building block for drug discovery and medicinal chemistry.
| Brand | Ossila |
|---|---|
| CAS number | 22282-75-3 |
| Molecular formula | C5H3FIN |
| Purity | >97% |
| Category | — |
| Pack sizes | 500 mg, 1 g, 2 g, 5 g |
| Physical form | Off-White Powder/Fibers |
| Storage | — |
- Product code: B3261
- Molecular Weight: 222.99 g/mol
- Synonyms: 4-Iodo-3-fluoropyridine
- Melting Point: 85 °C – 89 °C
- Classification / Family: Fluorinated building blocks, Heterocyclic building blocks, Pyridine building blocks, APIs, Organic synthesis
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