Ossila 3′-Fluoro-4′-methoxyacetophenone B2631

3′-Fluoro-4′-methoxyacetophenone (CAS 455-91-4) is a fluorinated acetophenone building block carrying both a fluorine and a methoxy group on the aromatic ring. Supplied by Ossila as an off-white powder with >98% purity, it serves as a starting material in drug discovery, medicinal chemistry and biochemistry research.

Its main role is in preparing chalcone derivatives: aldol condensation with benzaldehydes gives these α,β-unsaturated ketones, which find use as active pharmaceutical ingredients (APIs) and fluorescent dyes. Reacting the resulting chalcones with hydrazine derivatives leads to pyrazoles such as the anti-inflammatory drug celecoxib, while Juliá–Colonna epoxidation converts chalcones into epoxides.

The compound also takes part in the Mannich reaction with formaldehyde and secondary amines, giving β-amino-carbonyl compounds known as Mannich bases. Its several functional groups make it a convenient intermediate for straightforward synthesis.

• Synthesis of chalcone derivatives through aldol condensation with benzaldehydes.
• Preparation of pyrazole derivatives, such as celecoxib, from chalcones and hydrazine derivatives.
• Production of epoxides from chalcone derivatives via Juliá–Colonna epoxidation.
• Formation of β-amino-carbonyl compounds (Mannich bases) in the Mannich reaction with formaldehyde and secondary amines.
• Building block for drug discovery, medicinal chemistry and biochemistry research.

• Product code: B2631
• Full Name: 1-(3-fluoro-4-methoxyphenyl)ethan-1-one
• Synonyms: 1-(3-Fluoro-4-methoxyphenyl)-1-ethanone
• M​olecular Weight: 168.17 g/mol
• Classification / Family: Fluorinated building blocks, Acetophenone building blocks, Heterocycles, APIs
• Melting Point: 92 °C – 94 °C

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