3-Fluoro-4-methoxybenzoic acid (CAS 403-20-3), also known as 3-fluoro-p-anisic acid, is a fluorinated building block derived from para-anisic acid. Supplied as a white powder with a purity of 98%, it serves as an intermediate for drug discovery, medicinal chemistry and biochemistry research.
The molecule carries several functional groups. Its carboxylic acid group is the main site of reactivity, while the fluorine substituent allows nucleophilic aromatic substitution. Fischer esterification gives esters bearing a ligustrazine moiety, which have been studied for the treatment of Alzheimer's disease.
Treatment with thionyl chloride converts the acid into the corresponding benzoyl chloride, a more reactive species suited to Friedel-Crafts acylation. The acid can also be turned into a hydrazide, which acts as a precursor for oxadiazoles investigated for antimicrobial use.
- Intermediate in the preparation of APIs targeting Alzheimer's disease via ligustrazine-containing esters.
- Conversion to benzoyl chloride for Friedel-Crafts acylation reactions.
- Preparation of hydrazides used in synthesising oxadiazoles for antimicrobial applications.
- Fluorinated building block for drug discovery and medicinal chemistry research.
| Brand | Ossila |
|---|---|
| CAS number | 403-20-3 |
| Molecular formula | C8H7FO3 |
| Purity | 98% |
| Category | — |
| Pack sizes | 5 g, 10 g, 25 g |
| Physical form | White powder |
| Storage | — |
- Product code: B2821
- Molecular Weight: 170.14 g/mol
- Synonyms: 3-Fluoro-p-anisic Acid
- Classification / Family: Fluorinated building blocks, Benzoic acid building blocks, Anisic acid building blocks, APIs
- Melting Point: 211 °C – 213 °C
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