3-Fluoro-4-morpholinoaniline (CAS 93246-53-8) is a fluorinated heterocyclic building block supplied at >98% purity as an off-white to pale beige powder. Its structure joins a fluorinated aniline to morpholine, a ring carrying both amine and ether functionality, giving chemists several reactive sites for straightforward synthesis.
The free primary amine condenses with aldehydes to give Schiff bases. One such Schiff base inhibited biofilm formation with an IC 50 of 12.97 μM, outperforming linezolid (IC 50 of 15.93 μM). The compound can also be converted into sulfonamide and carbamate derivatives showing antimicrobial activity, with minimum inhibitory concentrations of 6.25-25.0 μg/mL.
In materials research, phenylenediamine carbon nanodots decorated with 4-morpholinoaniline reached a higher photoluminescence quantum yield, rising from 28.3% to 41.8%. The fluorinated analogue offers a way to adjust the emission wavelength of such carbon nanodots, supporting work on OLEDs and light-emitting materials.
- Synthesis of Schiff bases by condensation with aldehydes.
- Preparation of sulfonamide and carbamate derivatives with antimicrobial activity.
- Intermediate for active pharmaceutical ingredient (API) and drug discovery research.
- Surface modification of carbon nanodots to tune emission wavelength.
- Building block for OLED and light-emitting material development.
| Brand | Ossila |
|---|---|
| CAS number | 93246-53-8 |
| Molecular formula | C10H13FN2O |
| Purity | >98% |
| Category | — |
| Pack sizes | 25 g, 50 g |
| Physical form | Off-white to pale beige powder |
| Storage | — |
- Product code: B1781
- Molecular Weight: 196.22 g/mol
- Melting Point: 121 °C – 123 °C
- Synonyms: 4-(2-Fluoro-4-aminophenyl)morpholine, 3-Fluoro-4-morpholin-4-yl-phenylamine, 3-Fluoro-4-(4-morpholinyl)-benzenamine
- Classification: Fluorinated building block, Heterocyclic building block
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