3-Fluoro-4-(trifluoromethyl)benzoic acid (CAS 115754-21-7) is a fluorinated benzoic acid building block supplied by Ossila as an off-white powder with >98% purity. Its aromatic ring carries both a fluorine and a trifluoromethyl group, giving chemists several functional handles for straightforward synthesis.
In coordination chemistry, the carboxylic acid group binds to metal centres such as dysprosium. This chelation has been used to build magnetic organometallic clusters whose structure can be tuned by pH and which show slow magnetic relaxation.
The compound is also widely explored in pharmaceutical research. It is a key intermediate in preparing potassium channel openers investigated for epilepsy treatment, formed through condensation with aminopyridine. This makes it relevant to drug discovery, medicinal chemistry and biochemistry work.
- Synthesis of active pharmaceutical ingredients (APIs) in drug discovery and medicinal chemistry.
- Preparation of potassium channel openers for epilepsy research via condensation with aminopyridine.
- Ligand for dysprosium-based magnetic organometallic clusters with pH-tuneable structures.
- General fluorinated building block for biochemistry and organic synthesis research.
| Brand | Ossila |
|---|---|
| CAS number | 115754-21-7 |
| Molecular formula | C8H4F4O2 |
| Purity | >98% |
| Category | — |
| Pack sizes | 10 g, 25 g, 50 g |
| Physical form | Off-white powder |
| Storage | — |
- Product code: B2791
- Molecular Weight: 208.11 g/mol
- Synonyms: α,α,α,3-Tetrafluoro-p-toluic acid
- Classification / Family: Fluorinated building blocks, Benzoic acid building blocks, APIs, Organometallic complexes
- Melting Point: 174 °C – 179 °C
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