3-Fluoro-5-(trifluoromethyl)benzoic acid (CAS 161622-05-5) is a fluorinated benzoic acid building block used as an intermediate in the synthesis of active pharmaceutical ingredients (APIs). The aromatic ring carries a fluorine atom at the 3-position and a trifluoromethyl group at the 5-position; these fluorinated substituents contribute good lipophilicity and binding affinity to the molecules built from it.
The carboxylic acid group makes the compound simple to couple onto molecular scaffolds through amination. It can also be transformed into the corresponding acyl chloride, opening routes to nucleophilic substitution and Friedel-Crafts acylation.
One reported example is an oligothiophene-based fusion inhibitor of influenza A virus capped with this acid, which showed an inhibition of 0.22 µM against membrane fusion between the virus and the host cell endosome. Ossila supplies the material as a white powder with >98% purity.
- Serves as a synthesis intermediate for active pharmaceutical ingredients.
- Acts as a fluorinated building block in drug discovery and medicinal chemistry.
- Attaches to molecular scaffolds via amination reactions.
- Converts to an acyl chloride for nucleophilic substitution and Friedel-Crafts acylation.
- Used to cap oligothiophene-based fusion inhibitors studied against influenza A virus.
| Brand | Ossila |
|---|---|
| CAS number | 161622-05-5 |
| Molecular formula | C8H4F4O2 |
| Purity | >98% |
| Category | — |
| Pack sizes | 2 g, 5 g, 10 g, 25 g |
| Physical form | White Powder |
| Storage | — |
- Product code: B3351
- Molecular Weight: 208.11 g/mol
- Synonyms: α,α,α,5-Tetrafluoro-m-toluic acid
- Classification / Family: Fluorinated building blocks, Benzoic acid building blocks, APIs
- Melting Point: 104 °C – 108 °C
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