3-Fluorobenzoic hydrazide (CAS 499-55-8) is a fluorinated building block based on benzoic acid and carrying a hydrazide group. Supplied at >97% purity as off white to beige fibers, it serves as an intermediate for preparing heterocyclic compounds in drug discovery, medicinal chemistry and biochemistry research.
Its hydrazide group acts as a nucleophile and reacts readily with electrophiles such as isothiocyanate derivatives. The adducts formed can then be cyclized into triazole-thione derivatives. Compounds made by this route have shown antimicrobial activity with a minimum inhibitory concentration (MIC) of 62.5 µg/mL, alongside low toxicity towards human cells.
Because the resulting heterocycles carry several functional groups, they are well suited to late-stage functionalization. Hydrazide derivatives as a class are known for bioactivity, the tuberculosis antibiotic isoniazid being one example. The compound is offered in 10 g and 25 g pack sizes.
- Synthesis intermediate for heterocyclic compounds.
- Reaction with isothiocyanate derivatives followed by cyclization to form triazole-thione derivatives.
- Preparation of candidate antimicrobial compounds for medicinal chemistry research.
- Building block for drug discovery and biochemistry research requiring late-stage functionalization.
| Brand | Ossila |
|---|---|
| CAS number | 499-55-8 |
| Molecular formula | C7H7FN2O |
| Purity | >97% |
| Category | — |
| Pack sizes | 10 g, 25 g |
| Physical form | Off white to beige fibers |
| Storage | — |
- Product code: B2721
- Molecular Weight: 154.14 g/mol
- Melting Point: 139 °C – 143 °C
- Synonyms: 3-Fluorobenzohydrazide, 3-Fluorobenzoic acid hydrazide, 3-Fluorobenzhydrazide
- Classification / Family: Fluorinated building blocks, Hydrazide building blocks, Heterocycles, APIs
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