Ossila 4,4'-(Benzo[c][1,2,5]thiadiazole-4,7-diyl)dibenzoic acid B3181

4,4'-(Benzo[c][1,2,5]thiadiazole-4,7-diyl)dibenzoic acid, also known as H2BTDB (CAS 1581774-76-6), is a rigid, linear organic linker for constructing metal-organic frameworks (MOFs). Its structure places a 4-benzoic acid group at each of the 4- and 7-positions of an electron-deficient benzo[c][1,2,5]thiadiazole core. It is supplied by Ossila as a yellow powder or crystal with purity above 98%.

Published work shows this ligand forming fluorescent frameworks with several metals. A Eu-based MOF with a large pore structure detected ethylamine and gossypol at limits of 1.30 μm and 4.32 μm. The Eu framework JXUST-11 responds to Al3+ and Ga3+ through fluorescence enhancement (2.9 and 10.2 ppm), while the Cd(II) framework JXUST-14 senses L-histidine through turn-on emission and a blue shift, reaching 11.1 ppm.

In a Zr-based MOF with UiO-68 topology, H2BTDB enabled selective sensing of 2,4,6-trinitrophenol (TNP) among competing nitroaromatic compounds, with a detection limit of 1.63 ppm in methanol suspension. The quenching is linked to energy and electron transfer plus interactions between TNP hydroxyl groups and the ligand's Lewis basic nitrogen sites.

• Synthesis of luminescent metal-organic frameworks using a rigid linear dicarboxylate linker.
• Fluorescent MOF sensors for detecting Al3+ and Ga3+ ions.
• Turn-on luminescent detection of L-histidine with Cd(II)-based frameworks.
• Dual-target sensing of ethylamine and gossypol with Eu-based MOFs.
• Selective detection of the nitroaromatic explosive 2,4,6-trinitrophenol (picric acid) using Zr-based MOFs.

• Product code: B3181
• M​olecular Weight: 376.39 g/mol
• Synonyms: H2BTDB, H2-TTPDC, 4,4'-(benzothiadiazole-4,7-diyl)dibenzoate
• Classification / Family: Benzo[c][1,2,5]thiadiazole, MOF ligands

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