4-Amino-2-(trifluoromethyl)pyridine (CAS 147149-98-2) is a fluorinated heterocyclic building block whose pyridine ring carries both an amine and a trifluoromethyl substituent. Supplied as white crystals with a purity above 98%, it is aimed at drug discovery, medicinal chemistry and biochemistry research.
This compound serves as an intermediate in the preparation of several active pharmaceutical ingredients (APIs). One example is naporafenib, a RAF inhibitor developed for treating RAF-driven cancers. It is also a starting point for pyridine-based ligands that stabilise hypervalent iodine reagents, which are used across many synthetic transformations.
Through a Chichibabin reaction, a second amine group can be installed at the para-position. The resulting diamine is used to build an oral checkpoint kinase inhibitor investigated for immunotherapy. Having multiple functional groups on one small scaffold makes the molecule straightforward to elaborate.
- Synthesis of active pharmaceutical ingredients such as the RAF inhibitor naporafenib.
- Preparation of pyridine-based ligands that stabilise hypervalent iodine reagents.
- Chichibabin amination to give intermediates for oral checkpoint kinase inhibitors used in immunotherapy research.
- General fluorinated building block for drug discovery and medicinal chemistry.
| Brand | Ossila |
|---|---|
| CAS number | 147149-98-2 |
| Molecular formula | C6H5F3N2 |
| Purity | >98% |
| Category | — |
| Pack sizes | 1 g, 2 g, 5 g |
| Physical form | White crystals |
| Storage | — |
- Product code: B2961
- Full Name: 2-(Trifluoromethyl)-4-pyridinamine
- Molecular Weight: 162.11 g/mol
- Synonyms: 2-(Trifluoromethyl)pyridin-4-amine, 2-Trifluoromethyl-4-amino-pyridine
- Classification: Fluorinated building blocks, Heterocyclic building blocks, Pyridine building blocks, APIs, Ligands
- Melting Point: 58 °C – 62 °C
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