4-Bromo-3-fluorobenzonitrile (CAS 133059-44-6, C7H3BrFN) is a fluorinated, brominated benzonitrile building block supplied by Ossila at >98% purity as a white powder or crystals. Carrying bromide, fluoride and nitrile groups on one aromatic ring, it works as a versatile molecular scaffold in drug discovery and medicinal chemistry.
The bromo group makes the compound a suitable partner for palladium-catalysed cross-coupling. One documented route uses a Stille coupling followed by conversion of the nitrile into an amidine with lithium bis(trimethylsilyl)amide to give bichalcophene fluorobenzamidines, antimutagenic compounds that lowered azide-induced mutation frequency by 69%.
Beyond pharmaceuticals, the compound serves as an intermediate for carbazole-derived dyes showing persistent room-temperature phosphorescence, with quantum yields reaching up to 22%.
- Molecular scaffold for building active pharmaceutical ingredients (APIs).
- Substrate for palladium-catalysed cross-coupling reactions such as Stille coupling.
- Precursor to antimutagenic bichalcophene fluorobenzamidines.
- Intermediate for carbazole-based persistent room-temperature phosphorescent dyes.
| Brand | Ossila |
|---|---|
| CAS number | 133059-44-6 |
| Molecular formula | C7H3BrFN |
| Purity | >98% |
| Category | — |
| Pack sizes | 5 g, 10 g, 25 g, 50 g |
| Physical form | White Powder/Crystals |
| Storage | — |
- Product code: B3241
- Molecular Weight: 200.01 g/mol
- Synonyms: 4-Cyano-2-fluorobromobenzene, 3-Fluoro-4-bromocyanobenzene
- Melting Point: 92 °C – 97 °C
- Classification: Fluorinated building blocks, Non-heterocyclic building blocks, Brominated building blocks, Benzonitrile building blocks, APIs, Phosphorescent dyes
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