4-Bromo-6-fluoroquinoline (CAS 661463-17-8) is a dihalogenated quinoline building block supplied as an off-white powder with a purity above 98%. Quinoline is a bicyclic heterocycle in which a benzene ring is fused to a pyridine ring, and its derivatives appear frequently as active pharmaceutical ingredients (APIs).
This compound serves as an intermediate in the synthesis of linrodostat, an indoleamine 2,3-dioxygenase inhibitor developed for anti-cancer treatment. Its two halogen substituents offer separate reaction handles: the bromide takes part in Pd-catalyzed coupling reactions, while the fluoride is open to nucleophilic aromatic substitution, making stepwise functionalisation straightforward.
Beyond medicinal chemistry, its aromatic bicyclic core makes 4-bromo-6-fluoroquinoline a useful starting point for preparing dyes used in OLEDs and solar cells. It is offered in 500 mg, 1 g and 2 g pack sizes.
- Intermediate in the synthesis of linrodostat, an indoleamine 2,3-dioxygenase inhibitor for anti-cancer treatment.
- Fluorinated pyridine building block for drug discovery and medicinal chemistry research.
- Substrate for Pd-catalyzed coupling reactions at the bromide position.
- Substrate for nucleophilic aromatic substitution at the fluoride position.
- Precursor for dyes used in OLED and solar cell applications.
| Brand | Ossila |
|---|---|
| CAS number | 661463-17-8 |
| Molecular formula | C9H5BrFN |
| Purity | >98% |
| Category | — |
| Pack sizes | 500 mg, 1 g, 2 g |
| Physical form | Off-white powder |
| Storage | — |
- Product code: B2971
- Molecular Weight: 226.05 g/mol
- Melting Point: 77 °C – 78 °C
- Classification / Family: Fluorinated building blocks, Heterocyclic building blocks, Quinoline building blocks, APIs, Dyes
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