4-Bromo-8-fluoroquinoline (CAS 927800-38-2) is a heterocyclic quinoline building block carrying both a bromine and a fluorine substituent. It serves as an intermediate for introducing active quinoline units in drug discovery, where fluoroquinolines are widely found as active pharmaceutical ingredients such as antibiotics. Derivatives of 8-fluoroquinoline have also shown activity against insects, nematodes and mites in agricultural chemistry.
Because it offers several functional groups, the compound is well suited to substrate scope work in synthetic methodology research. The bromo position allows it to act as an end-capping unit in Pd-catalysed cross-coupling reactions, extending the chromophore of other molecules; one reported use is boosting the fluorescence signal of a cyclobarbital molecularly imprinted polymer for electrochemical sensing.
Ossila supplies this material at >98% purity as a white to light yellow powder or crystal, with a melting point of 112 °C – 113 °C.
- Intermediate for building quinoline-based active pharmaceutical ingredients such as antibiotics.
- Precursor for 8-fluoroquinoline derivatives explored as agricultural chemicals against insects, nematodes and mites.
- Substrate for synthetic methodology and substrate scope studies.
- End-capping unit in Pd-catalysed cross-coupling to extend chromophores for dyes and DSSCs.
- Enhancing fluorescence of molecularly imprinted polymers for electrochemical sensors.
| Brand | Ossila |
|---|---|
| CAS number | 927800-38-2 |
| Molecular formula | C9H5BrFN |
| Purity | >98% |
| Category | — |
| Pack sizes | 500 mg, 1 g, 2 g |
| Physical form | White to light yellow powder/crystal |
| Storage | — |
- Product code: B1891
- Molecular Weight: 226.05 g/mol
- Melting Point: 112 °C – 113 °C
- Classification / Family: Quinoline derivatives, Fluorinated building blocks, Heterocyclic building block, Dyes, DSSCs, Sensors, APIs
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