4-Chloro-3-fluoroaniline (CAS 367-22-6) from Ossila is a dihalogenated aniline carrying a chlorine atom at the para position and a fluorine atom at the meta position. Supplied as a grey powder or crystals with a purity above 98%, it is used to introduce a halogenated aniline unit into target molecules.
In medicinal chemistry, this compound takes part in nucleophilic substitution reactions during the preparation of antimalarial candidates. Adding the chloro and fluoro groups has been reported to raise potency markedly, bringing the EC50 against the Plasmodium falciparum parasite down to 27 nM. The same building block appears in active pharmaceutical ingredients such as piperidine derivatives explored for antiviral therapy and quinazolines studied as anticancer agents.
Beyond drug discovery, 4-chloro-3-fluoroaniline is well suited as a monomer for fluorinated polyanilines prepared by Buchwald-Hartwig amination, supporting research into semiconducting polymers. It is available in 5 g and 10 g packs.
- Building block for synthesising antimalarial agents through nucleophilic substitution reactions.
- Intermediate for piperidine derivatives investigated as antiviral treatments.
- Precursor for quinazoline-based anticancer agents.
- Monomer for fluorinated, semiconducting polyanilines made via Buchwald-Hartwig amination.
| Brand | Ossila |
|---|---|
| CAS number | 367-22-6 |
| Molecular formula | C6H5ClFN |
| Purity | >98% |
| Category | — |
| Pack sizes | 5 g, 10 g |
| Physical form | Grey powder/crystals |
| Storage | — |
- Product code: B2681
- Molecular Weight: 145.56 g/mol
- Synonyms: 4-Chloro-3-fluorophenylamine, 4-chloro-3-fluorobenzenamine
- Classification / Family: Fluorinated building blocks, Aniline building blocks, APIs, Semiconductors
- Melting Point: 58 °C – 62 °C
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