4-Chloro-7-trifluoromethylquinoline-3-carboxylic acid ethyl ester (CAS 21168-42-3) is a fluorinated heterocyclic building block supplied as a solid with purity above 98%. Structurally it is the ethyl ester of quinoline-3-carboxylic acid, carrying two electron-withdrawing groups: a chloro substituent and a trifluoromethyl group. It serves as an intermediate for active pharmaceutical ingredients (APIs) and dye-sensitized solar cells (DSSCs).
In medicinal chemistry, quinoline derivatives such as this one are studied as antimicrobials. Research indicates that coupling this unit to cell-penetrating peptides can improve their ability to enter cells: the trifluoromethyl group takes up protons, raising pH, destabilising membranes and causing osmotic swelling of endosomes.
For materials work, the lone pair on the ring nitrogen can coordinate to metal centres to form dye complexes for DSSCs, while the chloro group offers a handle for further functionalisation, for example building bidentate ligands for bioimaging and sensing.
- Intermediate for the synthesis of active pharmaceutical ingredients.
- Building block for antimicrobial research in medicinal chemistry.
- Modification of cell-penetrating peptides to enhance cell penetration.
- Preparation of metal dye complexes for dye-sensitized solar cells.
- Synthesis of bidentate ligands for bioimaging and sensors.
| Brand | Ossila |
|---|---|
| CAS number | 21168-42-3 |
| Molecular formula | C13H9ClF3NO2 |
| Purity | >98% |
| Category | — |
| Pack sizes | 500 mg, 1 g, 2 g |
| Physical form | Solid |
| Storage | — |
- Product code: B1901
- Full Name: Ethyl 4-chloro-7-(trifluoromethyl)-3-quinolinecarboxylate
- Molecular Weight: 303.66 g/mol
- Melting Point: 71 °C – 72 °C
- Classification / Family: Quinoline derivatives, Fluorinated building blocks, Heterocyclic building block, Dyes, DSSCs, APIs
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