4-Fluoro-2-iodobenzoic acid (CAS 56096-89-0) from Ossila is a fluorinated benzoic acid building block used as a molecular scaffold in organic synthesis, drug discovery and medicinal chemistry. Its benzene ring carries a carboxylic acid group, an iodine atom in the adjacent position and a fluorine atom in the opposite position, giving chemists three distinct functional groups to work with.
This combination makes it a flexible starting point for bioactive bicyclic heterocycles. Through a Sonogashira-type reaction it can give either isocoumarin or phthalide depending on temperature: the 6-endo-dig isocoumarin product forms selectively at 100 °C, while the 5-exo-dig phthalide product is favoured at 25 °C.
The compound also serves as a precursor to pseudocyclic benziodoxole tosylates, hypervalent iodine oxidants prepared by ligand transfer between 4-fluoro-2-iodobenzoic acid and PhI(OH)OTs. It is supplied as an off-white powder with a purity above 98%.
- Building block and molecular scaffold for organic synthesis.
- Temperature-controlled synthesis of isocoumarins and phthalides via Sonogashira-type reactions.
- Preparation of pseudocyclic benziodoxole tosylates as hypervalent iodine oxidants.
- Intermediate for drug discovery and medicinal chemistry research.
| Brand | Ossila |
|---|---|
| CAS number | 56096-89-0 |
| Molecular formula | C7H4FIO2 |
| Purity | >98% |
| Category | — |
| Pack sizes | 1 g, 2 g, 5 g, 10 g |
| Physical form | Off-white powder |
| Storage | — |
- Product code: B3271
- Molecular Weight: 266.01 g/mol
- Synonyms: 2-Iodo-4-fluorobenzoic acid
- Melting Point: 143 °C – 147 °C
- Classification / Family: Fluorinated building blocks, Benzoic acid building blocks, Iodide building blocks, Molecular scaffolds, Organic synthesis, Hypervalent iodine oxidants
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