4-Fluoro-3-methylbenzoic acid (CAS 403-15-6), also known as 4-fluoro-m-toluic acid, is a fluorinated benzoic acid building block supplied as a white powder with >97% purity. Structurally, it is meta-toluic acid carrying a fluoro substituent at the 4-position, and it is used mainly in the synthesis of active pharmaceutical ingredients (APIs).
Its value in synthesis comes from several reactive sites. The carboxylic acid can be used to couple the molecule onto molecular scaffolds, or it can be reduced to a hydroxy or aldehyde group to open up other reaction pathways. The methyl group can undergo benzylic bromination, and the brominated intermediate can then be taken forward to build bicyclic heterocycles.
In published work, an imidazopyridine analog derived from this acid showed a potency of 0.1 nM as an anticoccidial agent. The compound suits drug discovery, medicinal chemistry and biochemistry research.
- Building block for the synthesis of active pharmaceutical ingredients (APIs).
- Attachment to molecular scaffolds through its carboxylic acid group.
- Benzylic bromination of the methyl group to prepare intermediates for bicyclic heterocycles.
- Preparation of imidazopyridine analogs studied as anticoccidial agents.
- General use in drug discovery, medicinal chemistry and biochemistry.
| Brand | Ossila |
|---|---|
| CAS number | 403-15-6 |
| Molecular formula | C8H7FO2 |
| Purity | >97% |
| Category | — |
| Pack sizes | 5 g, 10 g, 25 g, 50 g |
| Physical form | White powder |
| Storage | — |
- Product code: B3311
- Molecular Weight: 154.14 g/mol
- Synonyms: 4-Fluoro-m-toluic acid
- Classification / Family: Fluorinated building block, Benzoic acid building blocks, APIs
- Melting Point: 164 °C – 168 °C
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