4′-Fluoro-3′-nitroacetophenone (CAS 400-93-1), also known as 1-(4-fluoro-3-nitrophenyl)ethanone, is an acetophenone derivative carrying both a fluoro and a nitro substituent. Supplied by Ossila at >98% purity as light brown crystals, it is a versatile building block for drug discovery, medicinal chemistry and biochemistry.
Its three functional groups (fluoride, nitro and ketone) can each be modified independently, making the compound a convenient scaffold for active pharmaceutical ingredients. In one reported route to a Trypanosoma cruzi inhibitor, relevant to Chagas disease, the fluoride undergoes nucleophilic aromatic substitution, the ketone is aminated and the nitro group is reduced; the final compound showed a potency of 8 nM against Tc infection.
The molecule is also used to build bicyclic heterocycles such as chromen derivatives. It is available in 5 g, 10 g, 25 g and 50 g packs.
- Molecular scaffold for the synthesis of active pharmaceutical ingredients.
- Starting material for Trypanosoma cruzi inhibitors studied for Chagas disease.
- Synthesis of bicyclic heterocycles such as chromen derivatives.
- Fluorinated and nitro building block for medicinal chemistry and drug discovery research.
| Brand | Ossila |
|---|---|
| CAS number | 400-93-1 |
| Molecular formula | C8H6FNO3 |
| Purity | >98% |
| Category | — |
| Pack sizes | 5 g, 10 g, 25 g, 50 g |
| Physical form | Light brown crystals |
| Storage | — |
- Product code: B3321
- Full Name: 1-(4-Fluoro-3-nitrophenyl)ethanone
- Molecular Weight: 183.14 g/mol
- Synonyms: 3-Acetyl-6-fluoronitrobenzene, 4-Acetyl-1-fluoro-2-nitrobenzene
- Classification / Family: Fluorinated building blocks, Nitro building blocks, Acetophenone building blocks, APIs
- Melting Point: 47 °C – 51 °C
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