4-Fluorobenzenesulfonamide (CAS 402-46-0) from Ossila is a fluorinated benzenesulfonamide with para substitution, supplied as a white powder at >98% purity. It serves as a synthesis intermediate in drug discovery, medicinal chemistry and the preparation of fluorophores for bioimaging.
The molecule carries a sulfonyl group capped with an amine, which allows further functionalization via nucleophilic substitution. Reported examples include condensation with benzaldehyde to give (E)-N-(4-fluorobenzylidene)-4-fluorobenzenesulfonamide, an antimicrobial compound, and reaction with carbon disulfide and a platinum complex to prepare a bis(dithiocarbimato)-platinum(II) candidate anti-tumour agent. It has also been used to build PI3K/mTOR dual inhibitors with half maximal inhibitory concentrations reaching 2.88 ± 0.58 µM.
Beyond pharmaceutical work, the compound has been applied to modify rhodamine dyes, allowing systematic adjustment of their spirocyclization equilibrium for high-resolution imaging. It is offered in 10 g, 25 g and 50 g packs.
- Synthesis of antimicrobial (E)-N-(4-substituted benzylidene)-4-fluorobenzenesulfonamides.
- Preparation of platinum(II) dithiocarbimato complexes studied as potential anti-tumour drugs.
- Design and synthesis of phenylsulfonylurea-based PI3K/mTOR dual inhibitors.
- Functionalization of rhodamines to tune spirocyclization for super-resolution microscopy.
- General building block for drug discovery and medicinal chemistry research.
| Brand | Ossila |
|---|---|
| CAS number | 402-46-0 |
| Molecular formula | C6H6FNO2S |
| Purity | >98% |
| Category | — |
| Pack sizes | 10 g, 25 g, 50 g |
| Physical form | White powder |
| Storage | — |
- Product code: B2461
- Molecular Weight: 175.18 g/mol
- Synonyms: p-Fluorobenzenesulfonamide, 4-Fluorobenzene-1-sulfonamide
- Classification / Family: Fluorinated building block, Sulfonamides, APIs, Fluorophores
- Melting Point: 124 °C – 127 °C
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