4-Hydroxy-2-(trifluoromethyl)benzoic acid (CAS 320-32-1) is a fluorinated benzoic acid building block supplied by Ossila as a white powder with >98% purity. Its benzene ring carries three functional groups (a hydroxyl, a carboxylic acid and a trifluoromethyl group), giving chemists several handles for straightforward synthesis.
Because the hydroxyl and carboxylic acid groups sit para to each other, the compound is well suited to building linear molecules. Polyesters containing its segments can self-assemble into spherulite crystals used to make optical vortex beam generators, and reaction with alkylated acyl chlorides yields smectic C liquid crystals.
In medicinal chemistry, the acid can be coupled to molecular scaffolds such as benzofuran derivatives by esterification or amide formation, a route explored for antitubercular active pharmaceutical ingredients (APIs). It is relevant to drug discovery, liquid crystal and biochemistry research.
- Synthesis of polyesters that self-assemble into spherulite crystals for optical vortex beam generators.
- Preparation of smectic C liquid crystals through reaction with alkylated acyl chlorides.
- Attachment to benzofuran and other scaffolds via esterification or amide synthesis to produce antitubercular APIs.
- Use as a fluorinated building block in drug discovery and biochemistry research.
| Brand | Ossila |
|---|---|
| CAS number | 320-32-1 |
| Molecular formula | C8H5F3O3 |
| Purity | >98% |
| Category | — |
| Pack sizes | 1 g, 2 g |
| Physical form | White powder |
| Storage | — |
- Product code: B2931
- Molecular Weight: 206.12 g/mol
- Synonyms: α,α,α-Trifluoro-4-hydroxy-o-toluic acid, 4-Carboxy-3-(trifluoromethyl)phenol
- Classification / Family: Fluorinated building blocks, Benzoic acid building blocks, Phenol building blocks, Heterocycles, Liquid crystals, APIs
- Melting Point: 159 °C – 161 °C
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