Ossila 5''-(4'-Formyl-[1,1'-biphenyl]-4-yl)-[1,1':4',1'':3'',1''':4''',1''''-quinquephenyl]-4,4''''-dicarbaldehyde B4591

TFBPB, also known as 1,3,5-Tris(4-formylbiphenyl)benzene or TFBB (CAS 805246-78-0), is a trialdehyde building block used to construct covalent organic frameworks (COFs). Its molecule is trigonal: a central benzene ring carries three 4-formyl-[1,1'-biphenyl] arms at the 1,3,5-positions, making it a three-way bridging linker. It is supplied as an off-white powder or crystals with a purity above 97%.

The three aldehyde groups take part readily in polycondensation, giving imine or carbon-carbon double bond linkages. Combined with 2,4,6-tris(4-aminophenyl)-1,3,5-triazine, it forms TFBPB-TAT-COF, a donor-acceptor framework whose band gap and catalytic sites suit it to light absorption and photocatalytic hydrogen evolution; this COF has also shown anticancer activity against HCT-116 human colorectal carcinoma cells.

Through Knoevenagel condensation with a vinyl tetrazine monomer, TFBPB yields TA-COF-2, a highly crystalline framework with a specific surface area of 1114 m2 g−1. TA-COF-2 acts as a photocatalyst for arylboronic acid oxidation and light-driven benzylamine coupling, and changes colour reversibly on exposure to HCl solution, HCl vapour and NH3 vapour.

• Linker for synthesising imine-linked and vinylene-linked covalent organic frameworks.
• Building photocatalytic COFs for the hydrogen evolution reaction.
• Preparing COF photocatalysts for arylboronic acid oxidation and light-induced benzylamine coupling.
• Developing colorimetric COF sensors for HCl and ammonia vapour.
• Research on COF materials with anticancer activity against colorectal carcinoma cells.

• Product code: B4591
• M​olecular Weight: 618.72 g/mol
• Synonyms: TFBPB, TFBB, 1,3,5-Tris(4-formylbiphenyl)benzene
• Classification / Family: Quinquephenyls, Aldehydes, COF ligands
• Melting Point: 158–160 °C

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