5-Bromo-2-fluoropyrimidine (CAS 62802-38-4) from Ossila is a fluorinated heterocyclic building block supplied as white crystals with >98% purity. Built on a pyrimidine core, a six-membered ring containing two nitrogen atoms, it carries a bromine and a fluorine atom in para positions relative to each other.
This arrangement gives chemists three distinct reactive handles. The fluoride can be displaced by nucleophilic aromatic substitution, the bromide takes part in Pd-catalyzed carbon-carbon coupling, and the 4- and 6-positions are open to acid-catalyzed vicarious nucleophilic substitution. Because each site can be addressed separately, the compound suits stepwise construction of linear macromolecules.
In materials work it acts as the electron-accepting ('electron-pulling') unit in push-pull molecules. In medicinal chemistry it is a key intermediate in the synthesis of reldesemtiv, a fast skeletal muscle troponin activator developed for conditions involving reduced muscle function.
- Synthesis intermediate for active pharmaceutical ingredients (APIs), including reldesemtiv.
- Electron-pulling moiety in the preparation of push-pull molecules.
- Stepwise synthesis of linear macromolecules via its orthogonal bromide and fluoride groups.
- Building block for drug discovery, medicinal chemistry and semiconductor research.
| Brand | Ossila |
|---|---|
| CAS number | 62802-38-4 |
| Molecular formula | C4H2BrFN2 |
| Purity | >98% |
| Category | — |
| Pack sizes | 1 g, 2 g, 5 g |
| Physical form | White crystals |
| Storage | — |
- Product code: B2921
- Molecular Weight: 176.98 g/mol
- Synonyms: 5-Bromo-2-fluoro-1,3-diazine
- Classification / Family: Fluorinated building blocks, Heterocyclic building blocks, APIs, Push-pull molecules
- Melting Point: 92 °C
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