5-Bromo-3-fluoropyridine-2-carboxylic acid (CAS 669066-91-5), also known as 5-bromo-3-fluoropicolinic acid, is a dihalogenated picolinic acid supplied as an off-white powder with >98% purity. Its bromo, fluoro and carboxylic acid groups give chemists several reactive handles, making it a convenient intermediate for building organometallic complexes used in catalysis and photoluminescent dyes.
In medicinal chemistry research, this compound has been used to synthesise positive allosteric modulators of the adenosine A2A receptor investigated for insomnia treatment.
For luminescent materials, it serves as a starting point for pyridine-triazole ligands that bind rhenium (Re). The route proceeds via a pyridinehydrazide, which is converted to a pyridine-oxadiazole with triethyl orthoformate and then reacted with aniline derivatives to give the triazole ligands. The resulting Re-pyridine-triazole complexes reach photoluminescence quantum yields of up to 55%.
- Synthesis intermediate for organometallic complexes used as catalysts.
- Preparation of pyridine-triazole ligands for rhenium photoluminescent complexes.
- Synthesis of allosteric adenosine A2A receptor modulators studied for insomnia treatment.
- Fluorinated pyridine and carboxylic acid building block for organic synthesis.
| Brand | Ossila |
|---|---|
| CAS number | 669066-91-5 |
| Molecular formula | C6H3BrFNO2 |
| Purity | >98% |
| Category | — |
| Pack sizes | 1 g, 2 g, 5 g |
| Physical form | Off-white Powder |
| Storage | — |
- Product code: B3411
- Full Name: 5-Bromo-3-fluoro-2-pyridinecarboxylic acid
- Molecular Weight: 220.00 g/mol
- Synonyms: 5-Bromo-3-fluoropicolinic acid, 5-Bromo-2-carboxy-3-fluoropyridine, 5-Bromo-3-fluoropyridin-2-carboxylic acid
- Melting Point: 175 °C – 180 °C
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