5-Chloro-2-fluorobenzoic acid (CAS 394-30-9), also known as 2-fluoro-5-chlorobenzoic acid, is a benzoic acid carrying both a fluorine and a chlorine substituent. Supplied by Ossila as a white powder with >98% purity, it serves as a versatile intermediate in drug discovery, medicinal chemistry and fuel cell materials research.
In medicinal chemistry, this compound has been used to build a pyrimidine-based Aurora kinase inhibitor. In that molecule the chlorine group strengthens binding to Aurora A, which helps drive the breakdown of oncoproteins.
For energy materials, it is a starting point for poly(phenylene ether)-based electrolyte membranes for proton exchange fuel cells. The acid is first turned into the benzoyl chloride with thionyl chloride, then reacted with anisole in a Friedel-Crafts step, and the polymer is finally assembled by nickel-mediated homocoupling. The resulting membrane reaches a proton conductivity of 8.60 × 10−3 S cm−1 at 80 °C and 30% relative humidity.
- Building block for the design of pyrimidine-based Aurora kinase inhibitors.
- Intermediate in the synthesis of active pharmaceutical ingredients (APIs).
- Precursor for poly(phenylene ether)-based polymer electrolyte membranes in proton exchange fuel cells.
- Fluorinated benzoic acid scaffold for drug discovery and medicinal chemistry research.
| Brand | Ossila |
|---|---|
| CAS number | 394-30-9 |
| Molecular formula | C7H4ClFO2 |
| Purity | >98% |
| Category | — |
| Pack sizes | 2 g, 5 g, 10 g, 25 g |
| Physical form | White powder |
| Storage | — |
- Product code: B3301
- Molecular Weight: 174.56 g/mol
- Synonyms: 2-Fluoro-5-chlorobenzoic acid
- Melting Point: 152 °C – 157 °C
- Classification / Family: Fluorinated building blocks, Benzoic acid building blocks, APIs, Electrolyte membranes
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