5-Chloro-2-fluorobenzonitrile (CAS 57381-34-7) from Ossila is a fluorinated benzonitrile building block supplied at >98% purity as white crystals. The fluorine sits next to the nitrile group and the chlorine is positioned opposite the fluorine, giving chemists several functional groups to work with in the synthesis of active pharmaceutical ingredients (APIs).
A documented use is the preparation of aminobenzo[b]thiophenes: reacting this compound with ethyl mercaptoacetate under basic conditions gives a scaffold used for kinase inhibitors, which can be further derivatized to tune binding affinity. It has also been used to prepare aryl ether inhibitors of Bacillus anthracis enoyl–ACP reductase.
With a molecular weight of 155.56 g/mol and a melting point of 67 °C – 70 °C, it suits drug discovery, medicinal chemistry and general organic synthesis work. Available in 2 g, 5 g, 10 g and 25 g packs.
- Synthesis of 3-aminobenzo[b]thiophene scaffolds for kinase inhibitors via reaction with ethyl mercaptoacetate under basic conditions.
- Preparation of aryl ether inhibitors of Bacillus anthracis enoyl–ACP reductase.
- Building block for the synthesis of active pharmaceutical ingredients (APIs).
- Intermediate for drug discovery, medicinal chemistry and organic synthesis.
| Brand | Ossila |
|---|---|
| CAS number | 57381-34-7 |
| Molecular formula | C7H3ClFN |
| Purity | >98% |
| Category | — |
| Pack sizes | 2 g, 5 g, 10 g, 25 g |
| Physical form | White Crystals |
| Storage | — |
- Product code: B3341
- Molecular Weight: 155.56 g/mol
- Synonyms: 5-Chloro-2-fluorocyanobenzene, 5-Chloro-2-fluorobenzyl cyanide
- Classification / Family: Fluorinated building blocks, Benzonitrile building blocks, APIs, Bicyclic heterocycles
- Melting Point: 67 °C – 70 °C
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