5-Difluoromethoxy-2-mercaptobenzimidazole (CAS 97963-62-7) from Ossila is a fluorinated heterocyclic building block for medicinal chemistry and API synthesis. Structurally, it is a benzimidazole carrying a thiol (mercapto) group at the 2-position and a difluoromethoxy substituent at the 5-position, and it is supplied as a white powder with a purity above 97%.
The compound is best known as a key intermediate in making pantoprazole, a proton pump inhibitor that lowers gastric acid output by inactivating H+-ATPase in the stomach and is used to treat stomach ulcers. In the usual route, it is coupled with 2-chloromethyl-3,4-dimethoxypyridinium hydrochloride, and the resulting product is then oxidised. It is also listed as Pantoprazole related compound C.
Its several functional groups make it a convenient starting point for further synthesis, including the preparation of α-glucosidase inhibitors studied for antidiabetic activity. It suits drug discovery, medicinal chemistry and biochemistry research.
- Synthesis intermediate for the proton pump inhibitor pantoprazole.
- Preparation of α-glucosidase inhibitors investigated as antidiabetic agents.
- Fluorinated heterocyclic building block for drug discovery and medicinal chemistry.
- Reference material related to pantoprazole (Pantoprazole related compound C) in impurity studies.
| Brand | Ossila |
|---|---|
| CAS number | 97963-62-7 |
| Molecular formula | C8H6F2N2OS |
| Purity | >97% |
| Category | — |
| Pack sizes | 25 g, 50 g |
| Physical form | White powder |
| Storage | — |
- Product code: B2991
- Full Name: 5-(Difluoromethoxy)-1,3-dihydro-2H-benzimidazole-2-thione
- Molecular Weight: 216.21 g/mol
- Synonyms: 5-(Difluoromethoxy)-2-benzimidazolethiol, Pantoprazole related compound C
- Classification / Family: Fluorinated building blocks, Heterocyclic building blocks, Benzimidazole building blocks, APIs
- Melting Point: 239 °C – 243 °C
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