5-Fluoro-2-methylbenzoic acid (CAS 33184-16-6) from Ossila is a fluorinated derivative of ortho-toluic acid, also known as 5-fluoro-o-toluic acid. Supplied as a white powder with >98% purity, it serves as a versatile building block for drug discovery, medicinal chemistry and biochemistry, with several functional groups that make synthetic routes straightforward.
In organic synthesis, the compound can be combined with saturated ketones under bimetallic Ir/Cu catalysis to give phthalides, bicyclic heterocycles found in dyes and fungicides. It has also been used to prepare benzamide derivatives studied as HIV-1 integrase inhibitors for antiviral therapy.
Through a lithiation reaction with benzonitrile, it gives access to 3-arylisoquinolinones. These products show antiproliferative effects on cancer cells by binding microtubules, suppressing tubulin polymerization and triggering apoptosis.
- Intermediate in the synthesis of active pharmaceutical ingredients (APIs).
- Substrate for Ir/Cu-catalyzed annulation with saturated ketones to form phthalides.
- Preparation of benzamide derivatives investigated as HIV-1 integrase inhibitors.
- Synthesis of 3-arylisoquinolinones with antiproliferative activity against cancer cells via lithiation with benzonitrile.
- Fluorinated building block for drug discovery and medicinal chemistry research.
| Brand | Ossila |
|---|---|
| CAS number | 33184-16-6 |
| Molecular formula | C8H7FO2 |
| Purity | >98% |
| Category | — |
| Pack sizes | 5 g, 10 g, 25 g, 50 g |
| Physical form | White powder |
| Storage | — |
- Product code: B3381
- Molecular Weight: 154.14 g/mol
- Synonyms: 5-Fluoro-o-toluic acid, 2-Methyl-5-fluorobenzoic acid
- Classification / Family: Fluorinated building blocks, Benzoic acid building blocks, APIs, Bicyclic heterocycles
- Melting Point: 130 °C – 132 °C
—
—