5-Fluoroindole (5-Fluoro-1H-indole, CAS 399-52-0) is an indole derivative carrying a fluorine atom at the 5-position of its bicyclic heterocyclic ring. Supplied by Ossila at >98% purity as an off-white to pale beige powder, it serves as a fluorinated building block for drug discovery, OLED, DSSC and semiconductor research.
In biosynthesis work, the compound acts as a fluorine-labelled indole for producing tryptophan that can be tracked by 19F NMR. Proliferating Escherichia coli cells convert it to 5-fluorotryptophan with L-serine through an enzyme synthase-catalysed reaction.
For materials chemistry, its oxidation potential of 1.05 V vs SCE makes electrochemical polymerization straightforward. The resulting fluorinated polyindoles combine redox activity with a conductivity of 7.1 × 10-2 S/cm, and they emit blue light under fluorescence spectroscopy, pointing to possible use in OLEDs.
- Synthesis intermediate for active pharmaceutical ingredients in drug discovery.
- Fluorine-labelled precursor for tryptophan biosynthesis monitored by 19F NMR.
- Monomer for electrochemical polymerization into conductive, redox-active polyindoles.
- Building block for blue-emitting polymers studied for OLEDs.
- Intermediate for DSSC and semiconductor materials research.
| Brand | Ossila |
|---|---|
| CAS number | 399-52-0 |
| Molecular formula | C8H6FN |
| Purity | >98% |
| Category | — |
| Pack sizes | 5 g, 10 g |
| Physical form | Off-white to pale beige powder |
| Storage | — |
- Product code: B1711
- Full Name: 5-Fluoro-1H-indole
- Molecular Weight: 135.14 g/mol
- Melting Point: 45 °C – 48 °C
- Classification / Family: Fluorinated building block, Heterocyclic building block, APIs, OLEDs, DSSCs, Semiconductors
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