5-Fluorosalicylic acid (CAS 345-16-4), also called 5-fluoro-2-hydroxybenzoic acid, is a fluorinated salicylic acid building block supplied as a pale beige powder with >98% purity. Its benzoic acid core carries a hydroxyl group at the 2-position and a fluorine atom at the 5-position, giving several functional groups for straightforward synthesis.
Being an ortho-hydroxybenzoic acid, the compound chelates metals effectively. With terbium (Tb3+) it gives strongly fluorescent ternary complexes used in immunoassays. With copper (Cu2+) it forms three isomers, and which one dominates depends on pH, so these copper complexes are suited to pH sensing. It has also been incorporated into a flexible trifurcate titanium metalloligand that encapsulates silver nanoclusters in a tetrahedral geometry, supporting their growth and stability for non-linear optical and photoluminescent work.
In medicinal chemistry, 5-fluorosalicylic acid serves as a precursor for active pharmaceutical ingredients, including fluorinated deferasirox for chronic iron overload. It is offered in 10 g, 25 g and 50 g packs.
- Preparation of fluorescent terbium ternary complexes for time-resolved fluorescence immunoassays.
- Development of pH sensors based on pH-dependent copper(II) complex isomers.
- Synthesis of titanium metalloligands that stabilise silver nanoclusters for non-linear optical and photoluminescent applications.
- Building block for APIs such as fluorinated deferasirox in drug discovery.
- Ligand and precursor for metal complexes and dyes.
| Brand | Ossila |
|---|---|
| CAS number | 345-16-4 |
| Molecular formula | C7H5FO3 |
| Purity | >98% |
| Category | — |
| Pack sizes | 10 g, 25 g, 50 g |
| Physical form | Pale beige powder |
| Storage | — |
- Product code: B2321
- Molecular Weight: 156.11 g/mol
- Synonyms: 5-Fluoro-2-hydroxybenzoic acid, 2-Hydroxy-5-fluorobenzoic acid
- Melting Point: 177 – 179 °C
- Classification / Family: Fluorinated building block, Ligands, Fluorescence immunoassay, APIs, Sensors
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