(5S)-(−)-5-(Trifluoromethyl)-2-pyrrolidinone (CAS 1287211-10-2) is a fluorinated chiral heterocyclic building block supplied at >97% purity as a white powder or crystal. Structurally it is a five-membered lactam (γ-lactam) derived from 2-pyrrolidinone, carrying a trifluoromethyl group on a left-handed S-configured stereocentre.
The 2-pyrrolidinone scaffold appears in a number of bioactive compounds, such as cotinine, doxapram and seletracetam. The trifluoromethyl substituent adds lipophilicity, which makes this compound attractive as an intermediate in active pharmaceutical ingredient (API) development, while its defined chiral centre suits systematic structure-activity studies in medicinal chemistry.
Pyrrolidinone chemistry is also relevant to energy storage: polyvinylpyrrolidone (PVP), whose vinylpyrrolidone monomer can be made from pyrrolidinone and acetylene, serves as a binder that holds intercalation-type cathodes together in solid-state battery work. Multiple functional groups on the molecule support straightforward synthetic modification.
- Intermediate for the synthesis of active pharmaceutical ingredients.
- Chiral building block for systematic medicinal chemistry and drug discovery studies.
- Fluorinated heterocyclic starting material for general organic synthesis.
- Research into pyrrolidinone-based polymers for lithium solid-state batteries.
| Brand | Ossila |
|---|---|
| CAS number | 1287211-10-2 |
| Molecular formula | C5H6F3NO |
| Purity | >97% |
| Category | — |
| Pack sizes | 1 g, 2 g, 5 g |
| Physical form | White powder/crystal |
| Storage | — |
- Product code: B1861
- Full Name: (5S)-5-(Trifluoromethyl)pyrrolidin-2-one
- Molecular Weight: 153.10 g/mol
- Melting Point: Tm = 98 °C – 105 °C
- Classification / Family: Pyrrolidinone derivatives, Heterocyclic building block, Fluorinated building block, API synthesis intermediates, Batteries
—
—