6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride (CAS 84163-13-3) is a fluorinated heterocyclic building block used as a synthesis intermediate and molecular scaffold in medicinal chemistry and drug discovery. Its structure combines a benzisoxazole ring (an isoxazole fused to benzene), a piperidine ring and a fluorine substituent.
The compound is best known as an intermediate in the preparation of atypical antipsychotics such as risperidone, paliperidone and iloperidone, which are used to treat schizophrenia. Researchers also use it as a core scaffold when designing antimicrobial, antidepressant and anticancer candidates.
Its piperidine nitrogen offers a convenient handle for derivatisation: acylation with acyl chlorides and sulfonylation with sulfonyl chlorides proceed readily, and reaction with alkyl chlorides or bromides gives N-alkylated products. Ossila supplies it as a white powder with a purity of >98%, in 10 g, 25 g and 50 g pack sizes.
- Intermediate in the synthesis of atypical antipsychotics including risperidone, paliperidone and iloperidone.
- Molecular scaffold for developing antimicrobial agents.
- Building block for antidepressant and serotonin receptor ligand research.
- Starting material for anticancer and antiproliferative compound studies.
- Substrate for acylation, sulfonylation and N-alkylation in medicinal chemistry libraries.
| Brand | Ossila |
|---|---|
| CAS number | 84163-13-3 |
| Molecular formula | C12H14ClFN2O |
| Purity | >98% |
| Category | — |
| Pack sizes | 10 g, 25 g, 50 g |
| Physical form | White powder |
| Storage | — |
- Product code: B2201
- Molecular Weight: 256.70 g/mol
- Synonyms: R-56109 hydrochloride, 4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidine hydrochloride, 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
- Classification: Fluorinated building blocks, Heterocyclic building blocks, APIs, Drug discovery
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