6-Fluoro-4-chromanone (CAS 66892-34-0) is a fluorinated heterocyclic building block supplied as an off-white powder with >99% purity. Structurally it is a dihydropyran ring fused to benzene, carrying both a fluorine atom and a ketone group, which gives chemists two separate handles for further synthesis.
The fluorine substituent raises the compound's lipophilicity and makes the ring amenable to nucleophilic aromatic substitution, a route used to prepare chromophoric xerogels for sensing. The ketone group, meanwhile, can take part in aldol reactions for additional functionalization.
In medicinal chemistry, the chromanone scaffold serves in the preparation of enzyme inhibitors, including those targeting Sirtuin 2, an enzyme associated with aging-related diseases. Iodine-catalyzed oxidation converts it into a fully aromatic system, opening its use in dye-sensitized solar cells (DSSCs) and related dye and semiconductor work.
- Intermediate for synthesizing Sirtuin 2-selective enzyme inhibitors.
- Precursor for chromophoric silicate-based xerogels used in sensor applications.
- Building block for dyes in dye-sensitized solar cells (DSSCs) after iodine-catalyzed aromatization.
- Synthesis intermediate for semiconductors and organic photovoltaics.
| Brand | Ossila |
|---|---|
| CAS number | 66892-34-0 |
| Molecular formula | C9H7FO2 |
| Purity | >99% |
| Category | — |
| Pack sizes | 10 g, 25 g |
| Physical form | Off-white powder |
| Storage | — |
- Product code: B1581
- Full Name: 6-Fluoro-2,3-dihydro-4H-chromen-4-one
- Molecular Weight: 166.15 g/mol
- Synonyms: 6-Fluorochroman-4-one
- Classification / Family: Dyes, Semiconductor synthesis intermediates, organic photovoltaics
- Melting Point: Tm = 114 °C – 116 °C
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