6-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline (CAS 31009-34-4) is a fluorinated hydroxyquinoline building block from Ossila, supplied as an off-white powder with a purity of 98%. Its quinoline core carries trifluoromethyl, hydroxyl and fluoro substituents, giving chemists several functional handles for straightforward synthesis in drug discovery, medicinal chemistry and biochemistry research.
The compound can tautomerise to a quinolone form, in which the hydroxy group is converted to a ketone and the imine becomes an amine. It is a known precursor to thioquinolines: thiolation with phosphorus pentasulfide in pyridine yields intermediates used to build potent, selective and non-cytotoxic antitubercular agents.
Its hydroxyl group is also open to nucleophilic substitution, a route used to prepare antiplasmodial compounds investigated for malaria treatment. The material belongs to the fluorinated, heterocyclic and quinoline building block families and is also classed among APIs.
- Synthesis of thioquinoline intermediates for selective, non-cytotoxic antitubercular agents.
- Preparation of antiplasmodial agents for malaria research via nucleophilic substitution of the hydroxyl group.
- Use as a fluorinated heterocyclic building block in medicinal chemistry and drug discovery.
- Starting material for biochemistry research requiring a multifunctional quinoline scaffold.
| Brand | Ossila |
|---|---|
| CAS number | 31009-34-4 |
| Molecular formula | C10H5F4NO |
| Purity | 98% |
| Category | — |
| Pack sizes | 500 mg, 1 g, 2 g |
| Physical form | Off-white powder |
| Storage | — |
- Product code: B2981
- Full Name: 6-Fluoro-2-(trifluoromethyl)-4-quinolinol
- Molecular Weight: 231.15 g/mol
- Synonyms: 6-fluoro-2-(trifluoromethyl)quinolin-4-ol
- Classification / Family: Fluorinated building blocks, Heterocyclic building blocks, Quinoline building blocks, APIs
- Melting Point: 259 °C – 263 °C
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