6-Fluoronicotinic acid (CAS 403-45-2), also known as 6-fluoropyridine-3-carboxylic acid, is a fluorinated heterocyclic building block supplied by Ossila as a white powder with >98% purity. Its pyridine ring carries a carboxylic acid group at the 3-position and a fluorine atom at the 6-position, giving chemists more than one functional handle for straightforward synthesis.
Because the molecule is bioactive, it is widely chosen as a starting point for active pharmaceutical ingredients in drug discovery and medicinal chemistry. One example is a quinolin-8-yl-nicotinamide derivative prepared from this acid, which has been studied as a potential pancreatic cancer treatment.
The compound also serves as a molecular scaffold for building positron emission tomography (PET) tracers, which are used to visualise and quantify changes in metabolic processes. Its parent compound, nicotinic acid, is an important dietary supplement used against pellagra, a disease caused by vitamin B3 deficiency.
- Building block for the synthesis of active pharmaceutical ingredients in drug discovery.
- Molecular scaffold for preparing PET tracers to image and measure metabolic changes.
- Precursor for quinolin-8-yl-nicotinamide derivatives investigated in pancreatic cancer research.
- Fluorinated carboxylic acid reagent for medicinal chemistry and biochemistry research.
| Brand | Ossila |
|---|---|
| CAS number | 403-45-2 |
| Molecular formula | C6H4FNO2 |
| Purity | 98% |
| Category | — |
| Pack sizes | 1 g, 2 g, 5 g |
| Physical form | White powder |
| Storage | — |
- Product code: B2421
- Full Name: 2-Fluoro-5-pyridinecarboxylic acid
- Synonyms: 6-Fluoropyridine-3-carboxylic acid
- Molecular Weight: 141.10 g/mol
- Classification / Family: Fluorinated building blocks, Heterocyclic building blocks, APIs, Ligands
- Melting Point: 144 – 148°C
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