6-Fluoropyridine-2-carbonitrile (CAS 3939-15-9), also known as 2-cyano-6-fluoropyridine, is a fluorinated heterocyclic building block used in drug discovery, medicinal chemistry, biochemistry research and the preparation of metal-organic complexes. Its pyridine ring carries a nitrile group and a fluorine atom at the two positions ortho to the ring nitrogen, giving two reactive handles in a single small molecule.
The fluorine allows the pyridine unit to be coupled onto molecular scaffolds by nucleophilic aromatic substitution, while the nitrile can be converted with thiols or amines into thiazoles and imidazoles, heterocycles that appear widely in active pharmaceutical ingredients. As a ligand, it binds silver(I) to give a centrosymmetric dinuclear complex whose units are joined into a ladder-like structure by BF4- counteranions through Ag-F contacts.
Ossila supplies the compound at >97% purity as pale blue crystals with a melting point of 31 °C – 35 °C, in 1 g, 2 g and 5 g packs.
- Building block for introducing a fluoropyridine unit onto molecular scaffolds via nucleophilic aromatic substitution.
- Precursor for thiazoles and imidazoles through reaction of the nitrile group with thiols or amines.
- Intermediate in the synthesis of active pharmaceutical ingredients for drug discovery and medicinal chemistry.
- Ligand for preparing silver(I) metal-organic complexes.
| Brand | Ossila |
|---|---|
| CAS number | 3939-15-9 |
| Molecular formula | C6H3FN2 |
| Purity | >97% |
| Category | — |
| Pack sizes | 1 g, 2 g, 5 g |
| Physical form | Pale blue crystals |
| Storage | — |
- Product code: B2901
- Molecular Weight: 122.10 g/mol
- Synonyms: 2-Cyano-6-fluoropyridine
- Classification / Family: Fluorinated building blocks, Heterocyclic building blocks, Ligands, APIs
- Melting Point: 31 °C – 35 °C
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