7-Fluoro-4-hydroxycoumarin (CAS 2145-27-9) from Ossila is a fluorinated coumarin building block used as an intermediate in the synthesis of active pharmaceutical ingredients (APIs). It is supplied as an off-white powder with >98% purity, suited to drug discovery, medicinal chemistry and general organic synthesis.
The molecule is built on the benzopyrone core of coumarin, a benzene ring fused to a 2-pyrone and a scaffold widespread in plants, carrying a hydroxyl group at position 4 and fluorine at position 7. This makes it a convenient natural-product-type substrate with multiple functional groups for straightforward derivatisation. Its 3-position can be functionalised with unsaturated 2-ketoesters through an asymmetric Michael reaction catalysed by chiral bisoxazoline−copper(II) complexes, giving good yields and enantiomeric excess of up to 98% ee.
The compound also serves in a solvent-free, L-proline-catalysed three-component reaction with ammonium acetate and 3-formylchromone, producing chromeno[4,3-b]pyridinone derivatives that show anticancer, antibacterial and antimicrobial activity.
- Intermediate for the synthesis of active pharmaceutical ingredients.
- Substrate for asymmetric Michael reactions at the 3-position using chiral bisoxazoline−copper(II) catalysts.
- Preparation of chromeno[4,3-b]pyridinone derivatives with anticancer, antibacterial and antimicrobial activity.
- Fluorinated heterocyclic building block for drug discovery and medicinal chemistry research.
| Brand | Ossila |
|---|---|
| CAS number | 2145-27-9 |
| Molecular formula | C9H5FO3 |
| Purity | >98% |
| Category | — |
| Pack sizes | 100 mg, 250 mg, 500 mg |
| Physical form | Off-white powder |
| Storage | — |
- Product code: B3401
- Full Name: 7-Fluoro-4-hydroxy-2H-chromen-2-one
- Synonyms: 7-Fluoro-4-hydroxy-1(2H)-benzopyran-2-one
- Molecular Weight: 180.13 g/mol
- Melting Point: 220 °C – 225 °C
- Classification / Family: Fluorinated building blocks, Coumarin building blocks, Heterocyclic building blocks, APIs, Organic synthesis
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