8-Fluoro-4-hydroxy-2-methylquinoline (CAS 5288-22-2) is a fluorinated heterocyclic building block from Ossila, supplied at >98% purity as a pale cream to pale brown powder or crystal. Its core is quinoline, a pyridine ring fused to benzene, carrying a methyl group at position 2, a hydroxyl group at position 4 and a fluorine atom at position 8.
These several functional groups make the compound a convenient starting point for synthesis, supporting reactions such as nucleophilic substitution and enamine condensation with aldehydes. Because quinoline has a conjugated structure, it is widely used to build dyes for OLEDs and dye-sensitized solar cells (DSSCs), and the energy gap of the resulting molecules can be adjusted through functional group conversions.
Quinoline derivatives also frequently show biological activity, with quinine for malaria treatment being a familiar example. Such active pharmaceutical ingredients can be modified into fluorescent bioimaging agents for tracking cell activity in in vitro experiments.
- Synthesis of conjugated dyes for dye-sensitized solar cells (DSSCs).
- Preparation of materials for OLEDs with tunable energy gaps.
- Building block for drug discovery based on bioactive quinoline derivatives.
- Development of fluorescent bioimaging substances for monitoring cell activity in vitro.
| Brand | Ossila |
|---|---|
| CAS number | 5288-22-2 |
| Molecular formula | C10H8FNO |
| Purity | >98% |
| Category | — |
| Pack sizes | 1 g, 2 g, 5 g |
| Physical form | Pale cream to pale brown powder/crystal |
| Storage | — |
- Product code: B1871
- Full Name: 8-Fluoro-2-methyl-4-quinolinol
- Synonyms: 8-Fluoro-2-methylquinolin-4-ol
- Molecular Weight: 177.18 g/mol
- Melting Point: Tm = 230 °C – 236 °C
- Classification / Family: Quinoline derivatives, Heterocyclic building block, Fluorinated building block, Dyes, OLEDs, DSSCs
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