(S)-(+)-3-Fluoropyrrolidine hydrochloride (CAS 136725-53-6) is a chiral, fluorinated heterocyclic building block supplied as the pyrrolidinium chloride salt. The fluorine atom sits on the S-configured carbon at the 3-position, and the molecule carries a secondary amine that can coordinate to metals or react with electrophiles. It is offered at 97% purity as a pink/beige powder.
In materials research, the compound serves as a ligand for metal complexes. A cadmium perovskite ferroelectric built with this fluorinated pyrrolidine shows a Curie temperature (Tc) of 303 K, 63 K above that of comparable cadmium complexes made with unsubstituted pyrrolidine, bringing ferroelectric operation up to room temperature.
For medicinal chemistry, the amine attaches readily to molecular scaffolds by nucleophilic substitution, making it useful for preparing analogs of active pharmaceutical ingredients. One pyrazolopyridazine inhibitor of tyrosine regulated kinase modified with this building block reached a pIC50 of 6.73.
- Building block for preparing analogs of active pharmaceutical ingredients in drug discovery.
- Introducing a fluorinated S-chiral pyrrolidine motif onto scaffolds via nucleophilic substitution.
- Ligand for metal complexes, including cadmium-based molecular perovskite ferroelectrics with raised Curie temperature.
- General chiral and fluorinated intermediate for organic synthesis.
| Brand | Ossila |
|---|---|
| CAS number | 136725-53-6 |
| Molecular formula | C4H9ClFN |
| Purity | 97% |
| Category | — |
| Pack sizes | 1 g, 2 g, 5 g |
| Physical form | Pink/beige powder |
| Storage | — |
- Product code: B2341
- Molecular Weight: 125.57 g/mol
- Synonyms: (S)-(+)-3-Fluoropyrrolidine HCl, (3S)-3-Fluoropyrrolidine hydrochloride, (S)-3-Fluoropyrrolidine hydrochloride
- Classification: Fluorinated building block, Heterocyclic building block, Chiral building block, APIs, Ligands, Ferroelectrics
- Melting Point: 183 – 187 °C
- Optical Rotation: 8.88 ° (c = 1, methanol)
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