SB-505124 TCI B6056

Chemical Identity

Other names: 2-[4-(1,3-Benzodioxol-5-yl)-2-(tert-butyl)-1H-imidazol-5-yl]-6-methylpyridine · 2-[5-(Benzo[d][1,3]dioxol-5-yl)-2-(tert-butyl)-1H-imidazol-4-yl]-6-methylpyridine
CAS No.: 694433-59-5
PubChem: CID 9858940·SID 468590880
Formula: C20H21N3O2
Molecular weight: 335.41 g/mol
Purity: >98.0%(HPLC)
Reference databases: ChEBI·ChemSpider

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: 2-[4-(1,3-benzodioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl]-6-methylpyridine
SMILES: CC1=NC(=CC=C1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=C(C=C3)OCO4
InChIKey: WGZOTBUYUFBEPZ-UHFFFAOYSA-N
MDL: MDL20926329

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TCI B6056 (SB-505124) is a selective inhibitor of TGF-β type I receptors (ALK4, ALK5, and ALK7), commonly used as a reference compound in TGF-β/Smad signaling pathway studies. This compound is widely applied in cancer research to investigate tumor cell proliferation, metastasis, and epithelial-mesenchymal transition (EMT), as well as in developmental biology and stem cell research. It is available in 5 mg and 25 mg packaging variants, suitable for in vitro and cell-based assays.