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Description
TCI B6369, 5-Bromo-1-methyl-1H-imidazole (CAS 1003-21-0), is a versatile heterocyclic building block for the construction of substituted imidazole scaffolds. N-methylation removes the acidic N–H proton and locks the tautomeric form, which makes regiochemical outcomes considerably easier to control. The ring-bound bromine serves as a synthetic handle for palladium-catalysed cross-couplings such as Suzuki–Miyaura, Stille, Negishi, and Sonogashira, as well as for halogen–metal exchange to generate imidazolyl nucleophiles. AMI Scientific offers this TCI reagent in 5 g and 25 g pack sizes for medicinal chemistry, ligand synthesis, and materials research.
