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Description
TCI C1552 Methyl 2-(cyanomethyl)benzoate is an aromatic building block carrying a methyl ester and a cyanomethyl group in an ortho relationship. This arrangement is particularly valuable for intramolecular cyclization, providing efficient access to fused bicyclic and heterocyclic frameworks. The acidic methylene protons are readily deprotonated to generate a stabilized carbanion suitable for alkylation, acylation, and Claisen- or Dieckmann-type carbon–carbon bond formation. AMI Scientific supplies this TCI reagent in 5 g and 25 g packs for synthetic organic, medicinal chemistry, and pharmaceutical R&D laboratories.
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